19-P002 miR-196 is an essential early-stage regulator of tail regeneration, upstream of key spinal cord patterning events
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چکیده
منابع مشابه
19-P002 miR-196 is an essential early-stage regulator of tail regeneration, upstream of key spinal cord patterning events
Salamanders have the remarkable ability to regenerate many body parts following catastrophic injuries, including a fully functional spinal cord following a tail amputation. The molecular basis for how this process is so exquisitely well-regulated, assuring a faithful replication of missing structures every time, remains poorly understood. Therefore a study of microRNA expression and function du...
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sue is known as transdifferentiation, in which the local cells are able to dedifferentiate (lose the characteristics of their origin) and subsequently redifferentiate. Our lab has shown by transient lineage tracing that spinal cord cells (radial glial cells) can migrate into surrounding tissues and contribute to non-neural cells during regeneration [Science 298 (2002) 1993–1996]. In order to fo...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2009
ISSN: 0925-4773
DOI: 10.1016/j.mod.2009.06.790